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It is interesting to note that both a recent review in the journal Circulation and a new review by the FDA found that there wasn't a significant difference in testosterone levels between men who received oxymetholone or placebo in the study (i. , they had equal testosterone levels), and men who were either not treated with the steroid or did not respond to the placebo, . On the other hand, a large study in 2008 showed that oxymetholone reduces the ability of testosterone to bind to the androgen receptor in men with androgen deficiency, and in women with hypogonadism, which is a condition in which the androgen receptor is not functioning properly.

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